#1 Trusted Probiotic Among Therapists

Developed by Wasa Medicals AB in Sweden, ProBion dry tablets were used in recent human clinical study aimed at ascertaining effect of probiotics on gut bacteria in colon cancer patients. It has been found that two tablets of ProBion Clinica a day for an average of 31 days had wiped out a significant amount of cancer associated harmful bacteria and generated a plethora of beneficial bacteria with anti-inflammatory effects. It showed promise in using probiotics to mitigate dysbiosis and improve gut health for cancer prevention. It also showed that ProBion tablets delivered undamaged probiotic bacteria in the large intestines to achieve therapeutic effect. The study was conducted by scientists at the Sahlgrenska University Hospital in Gothenburg. Results published in July 2017 in BMJ Journal, a leading open access platform for scientific papers specialising in gastroenterology.

Wasa Medicals AB, based in Halmstad, Sweden, is a member of the International Probiotic Association (IPA). Led by CEO Lennart Cedgard, MD, the company developed the ProBion dry tablet matrix through collaboration with Swedish doctors and scientists, and has continuously researched probiotic dosage effect for 25 years. Mr Cedgard has over 35 years clinical experience in intestinal microecology and is contributor of papers on probiotics and microbiology to medical journals. In 2016 he co-founded ProBion Innovation Sweden AB (PISA), a biotechnology research company, to study innovative use of probiotics for alleviating diseases.

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ProBion Smart Tablet

How It Works?

Strain

We took well researched strains with hundreds of peer reviewed publications and spent last 25 years customizing them with patients. Ensuring their prolonged effectiveness according to digestive disorders - irrespective of age and sex

Research

Scientific approach. 25 years of dose-response research with quality assured by independent laboratories allowed us to successfully verify positive health effects of probiotics under certain conditions. We've published results in British Medical Journal

Probion Matrix

Probion Matrix - innovative freeze dry production technique efficiently delivers, feeds and protects vigorous and non-damaged bacteria in the gastrointestinal tract for extended periods of time. Makes it possible to use all kinds of lactobacilli or bifido strains in further research

Therapeutic Quality

It's no magic. Vigorous cultures protected & delivered by ProBion contribute to gut environment where many other "healthy" bacteria can thrive supporting overall wellbeing. “Colon Cancer Breakthrough: New Probiotic Treatment Markedly Reduces Cancer-Related Microbes”

ProBion Matrix

Innovative production technique

Innovative production technique efficiently delivers, feeds and protects vigorous and non-damaged bacteria in the gastrointestinal tract for extended periods of time.

Makes it possible to use all kinds of lactobacilli or bifidobacteria strains in further research.

  • ProBion Matrix Tablet efficiently delivers, feeds (synbiotic) and protects vigorous and non-damaged bacteria in the gastrointestinal tract for extended periods of time.
  • Cultures are protected against gastric and bile acids and additionally by mucus forming protective molecules of Xanthan.
  • Unique structure of this ingenious tablet form is produced with a low-compression technology where less than 10% of the conventional compression force is used. This ensures the greatest "aliveness" or viability of the bacteria cultures during production and after.
  • Dry tablet that contains vigorous bacteria embedded into a matrix with Inulin (considered as prebiotic metabolic fibre) and mucous forming Xanthan. Inulin consists of FPS (fructopolysaccharides) and FOS (fructooligosaccharides) defining both matrix protection and feed for the bacteria. Inulin and Xanthan regulate the disintegration profile of the tablet by forming a sheltering cover around the bacteria. The tablet slowly dissolves during the passage through the stomach and the small intestine. The bacteria are thus directly exposed to a large area of the digestive tract. This is unique for this tablet as compared to other tablets, powders, and capsules.
  • The ingenious tablets manufactured have profound sustained storage viability with a controlled timed release profile enabling viable bacteria to expose the gastrointestinal tract under prolonged duration. Collaboration with the research groups at the University of Gothenburg and the Sahlgrenska University Hospital yields an excellent platform for validation analyses. Wasa Medicals is a member of the International Probiotics Association. ProBion Innovation Sweden AB performs both clinical studies and basic science studies, regarding the effect of probiotics (beneficial non-pathogenic gut bacteria) on various different diseases, such as colon cancer, metabolic diseases, celiac disease, infertility and irritable bowel syndrome. We use the unique formulation of the ProBion tablet matrix to ensure excellent quality and high viability of the probiotic bacteria in every step of our studies.

The ProBion Matrix Tablet

Electron-microscopic photo from inside of a ProBion tablet produced according to Wasa Medical Group's "low-compression- technique".The fibres of inulin form round cavities in which the living probiotic cultures are sheltered until they reach the intestine. The tablet is unique and is the only tablet that can deliver high counts of viable lactic acid cultures to the right place in the gut.

ProBion Matrix Globules

The ProBion Matrix globules protect clusters of bacteria. The Matrix consists of round cavities in which the living probiotic cultures are sheltered until they reach the intestine.

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Viable but Freezed-Dried

The photos show what it looks like within one of the cavities. The bacteria are viable but freeze-dried and are activated when they reach the intestine. The tablet dissolves slowly and the viable bacteria are spread over a large area of the intestine. Together with the inulin fibres the bacteria start rebalancing the intestinal microflora

Last Image - A tablet produced
with “normal” compression forces.

When “normal” compression forces are used during production of tablets the major pat of the bacteria are killed. The structure of the tablet s similar to blocks of cement in which there are no space for living bacteria.

CONCLUSION - Bacteria in the ProBion Matrix Tablet are better preserved

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Bacterial Strains in ProBion

Only well documented and “Generally regarded as safe”

Lactobacillus bulgaricus LB-87

Bifidobacterium lactis BL-04

Lactobacillus acidophilus NCFM

Lactobacillus paracasei LPC-37

Lactobacillus plantarum LP-115

At Wasa Medicals we took well researched strains with hundreds of peer review publications and spent last 25 years customizing them with patients - ensuring their prolonged effectiveness according to digestive disorders - irrespective of age and sex.

Bacterial Strains inside ProBion

Production according to HACCP standards and controlled by Swedish authorities.

Inside ProBion Smart Tablet

ProBion active

2 billions bacteria CFU / tablet

6 billions bacteria CFU / gram

150 tablets / container

unrest, speedy or loose digestion & travelling

150T

Lactobacillus plantarum LP-115

Lactobacillus paracasei LPC-37

Lactobacillus bulgaricus LB-87

ProBion basic

4 billions bacteria CFU / tablet

12 billions bacteria CFU / gram

150 tablets / container


sensitive, slow or constipated digestion

150T

Bifidobacterium lactis BL-04

Lactobacillus plantarum LP-115

Lactobacillus bulgaricus LB-87

ProBion clinica

10 billions bacteria CFU / tablet

30 billions bacteria CFU / gram

50/150 tablets / container

for all to start, as high strength support for antibiotic intake or detox-cure

50/150T

Bifidobacterium lactis BL-04

Lactobacillus acidophilus NCFM

ProBion daily

6 billions bacteria CFU / tablet

18 billions bacteria CFU / gram

150 tablets / container

normal or altering digestion, most individuals

150T

Bifidobacterium lactis BL-04

Lactobacillus acidophilus NCFM

Lactobacillus plantarum LP-115

Lactobacillus paracasei LPC-37

Lactobacillus bulgaricus LB-87

What’s Else Inside ProBion Smart Tablet?

Bacteria

Lactobacilli and Bifidobacteria

Well documented and GRAS

(Generally regarded as safe)

Prebiotics

Inulin

Inulin promotes the growth and activity for the endogenous

flora. Often extracted from the roots of endives.

Xanthan

Mucus producing item manufactured by fermenting carbohydrates.

It protects the bacteria in the intestine and control the dissolution of the tablets optimizing the exposure of viable bacteria.

Magnesium stearate

Flowing qualities at the production. RSPO certificate.

Free from GMO, dairy, soy, wheat and gluten. Suitable for vegans, vegetarians, pregnant women, children and elders

Detoxification

Often taking ProBion will start a detoxification activity in the gut. During a period of 2-3 weeks some will experience detoxification symptoms, as chronic unhealthy problems will show more of an acute expression before getting away. This is normal as body adjust to the activity of healthy bacteria. It is advised to start dosing slowly with 1-2 tablets daily.

Healthy Promise

More life with ProBion...

Detoxification & Dosage

Often taking ProBion will start a detoxification activity in the gut with occurring effects could be experienced as impaired feeling of deterioration.. During period of 2-3 weeks some will experience detoxification symptoms, as chronic unhealthy problems will be show more of an acute expression before getting away. This is normal as body adjust to the activity of healthy bacteria therefore It is advised to start dosing slowly.
Dosage: Start with 1 tablet x 1 /week 1, 1 tablet x 2 /week 2 and 2 tablets x 2 /week 3 and thereafter as needed

Digestive Health & Probiotics

Detoxification Dysbiosis is linked to inflammatory related diseases

The intestinal microbiota play an important role in the digestion and absorption of food, modulation of the immune system, production of vitamins, protection against pathogens and regulation of hormones that impact diseases. Interaction between the normal microbiota and the human intestinal mucosa is essential for proper intestinal function. An imbalance within the intestinal microbiota (dysbiosis) may be caused by poor diet, infection, or treatment with antibiotics. Dysbiosis will affect cell proliferation in the colon mucosa and may lead to the development of adenomas (precancerous lesions of colon cancer). Intestinal microbial dysbiosis has also been observed in type-2- diabetes. Celiac disease is an inflammatory, autoimmune disease triggered by gluten, although gluten proteins are responsible for the symptoms of celiac disease, gastrointestinal infections may also play a role. Recent data show that the intestinal microbiota of celiac disease patients displays a greater bacterial diversity than healthy individuals.

Prevention of inflammatory related diseases

ProBion Innovation Sweden research is focused on developing a new approach directed towards prevention of disease, or on reversing early stages of disease. The intestinal microorganisms (the microbiota) have a profound influence on human health, and an imbalance within the microbiota (dysbiosis) has been shown to lead to development of disease. The number of individuals with inflammatory-related diseases is increasing, such as colorectal cancer, type-2 diabetes, celiac disease (gluten intolerance) and infertility. Early detection and preventive cost-effective treatment of these diseases will benefit both individuals and society. Our hypothesis is that the microbiota affects expression of mediators in inflammatory pathways in intestinal cells, and that this triggers development of disease. When restoring the normal microbiota by treatment with probiotics, aberrant mechanisms will be reversed and development of disease prevented.

See also ProBion Clinica given to colon cancer patients reduces more than 90% cancer related microbes

Meet The Board

ProBion Innovation Research Team

Katarina Ejeskär

Chief Research Officer

Victoria Rotter Sopasakis

Chief Chief Executive Officere

Yvonne Wettergren

Chairman Of The Board

Charles Hanson

Board Member

Lennart Cedgård

Board Member

Partner with ProBion

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