#1 Trusted Probiotic Among Therapists

Developed by Wasa Medicals AB in Sweden, ProBion dry tablets were used in recent human clinical study aimed at ascertaining effect of probiotics on gut bacteria in colon cancer patients. It has been found that two tablets of ProBion Clinica a day for an average of 31 days had wiped out a significant amount of cancer associated harmful bacteria and generated a plethora of beneficial bacteria with anti-inflammatory effects. It showed promise in using probiotics to mitigate dysbiosis and improve gut health for cancer prevention. It also showed that ProBion tablets delivered undamaged probiotic bacteria in the large intestines to achieve therapeutic effect. The study was conducted by scientists at the Sahlgrenska University Hospital in Gothenburg. Results published in July 2017 in BMJ Journal, a leading open access platform for scientific papers specialising in gastroenterology.

Wasa Medicals AB, based in Halmstad, Sweden, is a member of the International Probiotic Association (IPA). Led by CEO Lennart Cedgard, MD, the company developed the ProBion dry tablet matrix through collaboration with Swedish doctors and scientists, and has continuously researched probiotic dosage effect for 25 years. Mr Cedgard has over 35 years clinical experience in intestinal microecology and is contributor of papers on probiotics and microbiology to medical journals. In 2016 he co-founded ProBion Innovation Sweden AB (PISA), a biotechnology research company, to study innovative use of probiotics for alleviating diseases.

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ProBion Smart Tablet

How It Works?

Well-tested Strains

We choose strains with proven benefits supported by hundreds of peer-reviewed studies, and we combine them in a matrix with patented technology to ensure their safe passage to the gut where they can alleviate digestive disorders

Clinical Study

ProBion Clinica's positive probiotic effect was verified in a 2017 clinical study involving humans with colon problems. We also have 25 years of dose-response research, with efficacy of our probiotics validated by independent labs.

Innovative Matrix

The ProBion freeze dry, low-compression technique produces a unique dry tablet free from damage by oxygen and humidity. Bacteria slow-released into the gut, allowing greatest sustainability, deposition and activation.

Therapeutic Effect

Vigorous cultures protected and delivered to the gut help healthy flora thrive and ensure that they outnumber harmful bacteria, building the foundation for eliminating digestive disorders

ProBion Matrix

Innovative production technique

Innovative production technique efficiently delivers, feeds and protects vigorous and non-damaged bacteria in the gastrointestinal tract for extended periods of time.

  • ProBion Matrix Tablet efficiently delivers, feeds (synbiotic) and protects vigorous and non-damaged bacteria in the gastrointestinal tract for extended periods of time.
  • Cultures are protected against gastric and bile acids and additionally by mucus forming protective molecules of Xanthan.
  • Unique structure of this ingenious tablet form is produced with a low-compression technology where less than 10% of the conventional compression force is used. This ensures the greatest "aliveness" or viability of the bacteria cultures during production and after.
  • Dry tablet that contains vigorous bacteria embedded into a matrix with Inulin (considered as prebiotic metabolic fibre) and mucous forming Xanthan. Inulin consists of FPS (fructopolysaccharides) and FOS (fructooligosaccharides) defining both matrix protection and feed for the bacteria. Inulin and Xanthan regulate the disintegration profile of the tablet by forming a sheltering cover around the bacteria. The tablet slowly dissolves during the passage through the stomach and the small intestine. The bacteria are thus directly exposed to a large area of the digestive tract. This is unique for this tablet as compared to other tablets, powders, and capsules.
  • The ingenious tablets manufactured have profound sustained storage viability with a controlled timed release profile enabling viable bacteria to expose the gastrointestinal tract under prolonged duration. Collaboration with the research groups at the University of Gothenburg and the Sahlgrenska University Hospital yields an excellent platform for validation analyses. Wasa Medicals is a member of the International Probiotics Association. ProBion Innovation Sweden AB performs both clinical studies and basic science studies, regarding the effect of probiotics (beneficial non-pathogenic gut bacteria) on various different diseases, such as colon cancer, metabolic diseases, celiac disease, infertility and irritable bowel syndrome. We use the unique formulation of the ProBion tablet matrix to ensure excellent quality and high viability of the probiotic bacteria in every step of our studies.

The ProBion Matrix Tablet

Electron-microscopic photo from inside of a ProBion tablet produced according to Wasa Medical Group's "low-compression- technique". The fibres of inulin form round cavities in which the living probiotic cultures are sheltered until they reach the intestine. The tablet is unique and is the only tablet that can deliver high counts of viable lactic acid cultures to the right place in the gut.

ProBion Matrix Globules

The ProBion Matrix globules protect clusters of bacteria. The Matrix consists of round cavities in which the living probiotic cultures are sheltered until they reach the intestine.

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Viable but Freezed-Dried

The photos show what it looks like within one of the cavities. The bacteria are viable but freeze-dried and are activated when they reach the intestine. The tablet dissolves slowly and the viable bacteria are spread over a large area of the intestine. Together with the inulin fibres the bacteria start rebalancing the intestinal microflora

Last. A tablet produced
with “normal” compression forces.

When “normal” compression forces are used during production of tablets the major part of the bacteria are killed. The structure of the tablet s similar to blocks of cement in which there are no space for living bacteria.

CONCLUSION - Bacteria in the ProBion Matrix Tablet are better preserved

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Bacterial Strains in ProBion

Only well documented

Lactobacillus bulgaricus LB-87

Bifidobacterium lactis BL-04

Lactobacillus acidophilus NCFM

Lactobacillus paracasei LPC-37

Lactobacillus plantarum LP-115

At Wasa Medicals we took well researched strains with hundreds of peer review publications and spent last 25 years customizing them with patients - ensuring their prolonged effectiveness according to digestive disorders - irrespective of age and sex.

Production according to HACCP standards

Quality Assurance by Independent Labs

Inside ProBion Smart Tablet

ProBion active

2 billions bacteria CFU / tablet

6 billions bacteria CFU / gram

150 tablets / container

For the speedy or loose digestion & travelling

Lactobacillus plantarum

Lactobacillus paracasei

Lactobacillus bulgaricus

ProBion basic

4 billions bacteria CFU / tablet

12 billions bacteria CFU / gram

150 tablets / container


For slow or constipated digestion

Bifidobacterium lactis

Lactobacillus plantarum

Lactobacillus bulgaricus

ProBion clinica

10 billions bacteria CFU / tablet

30 billions bacteria CFU / gram

50/150 tablets / container

For sensitive, irregular digestion, as high strength support during antibiotic intake

Bifidobacterium lactis

Lactobacillus acidophilus

ProBion daily

6 billions bacteria CFU / tablet

18 billions bacteria CFU / gram

150 tablets / container

For normal digestion, reduces irregularities daily

Bifidobacterium lactis

Lactobacillus acidophilus

Lactobacillus plantarum

Lactobacillus paracasei

Lactobacillus bulgaricus

What else inside the ProBion Smart Tablet

Prebiotics

Inulin

Inulin promotes the growth and activity for the endogenous

flora. Often extracted from the roots of endives.

Xanthan

Mucus producing item manufactured by fermenting carbohydrates.

It protects the bacteria in the intestine and control the dissolution of the tablets optimizing the exposure of viable bacteria.

Magnesium stearate

A compound of magnesium and stearic acids, it is a flow agent that gives more consistency to tablets. RSPO certificate.

Recommended Dosage

Start with 1 tablet a day in the first week, and gradually increase to 2 tablets a day or more as needed.

Children under the age of 7 should take half the dosage of adults.
Infants should take 1/4 the dosage of adults with tablets ground into powder and mixed with water or milk, to be fed little by little throughout the day.

Free from GMO, dairy, soy, wheat and gluten. Suitable for vegans, vegetarians, pregnant women, children and elders

Healthy Promise

More life with ProBion...

Return to Balance

Probiotics serve to restore the balance of our intestinal bacteria. While promoting the growth of beneficial bacterial, they will also cause the dying off of harmful bacteria. This is a process of detoxification that can lead to healing crises in the form of intestinal discomfit and other symptoms associated to chronic health issues during the first 2-3 weeks. These symptoms will pass as the body adjusts to healthy gut flora, leading to long-term health improvement.

probion digestive heart

Dysbiosis and Inflammatory Diseases

Detoxification Dysbiosis is linked to inflammatory related diseases

The intestinal microbiota play an important role in the digestion and absorption of food, modulation of the immune system, production of vitamins, protection against pathogens and regulation of hormones that impact diseases. Interaction between the normal microbiota and the human intestinal mucosa is essential for proper intestinal function. An imbalance within the intestinal microbiota (dysbiosis) may be caused by poor diet, infection, or treatment with antibiotics. Dysbiosis will affect cell proliferation in the colon mucosa and may lead to the development of adenomas (precancerous lesions of colon cancer). Intestinal microbial dysbiosis has also been observed in type-2- diabetes. Celiac disease is an inflammatory, autoimmune disease triggered by gluten, although gluten proteins are responsible for the symptoms of celiac disease, gastrointestinal infections may also play a role. Recent data show that the intestinal microbiota of celiac disease patients display a more disturbing bacterial composition than for healthy individuals.

The Way Forward

Scientific Research by ProBion Innovation Sweden AB (PISA)

It is increasingly accepted by the medical community and society at large that intestinal microbiota form an important part of our immune system, and have a profound influence on our state of health or disease. With rising incidences of inflammatory diseases such as colorectal cancer, type-2 diabetes, celiac disease (gluten intolerance) and infertility, the need for prevention, early detection and cost-effective care has never been greater. Having first-hand experience with how probiotics can restore or enhance the balance of our intestinal microbiota, we at Wasa Medicals believe probiotics is the future of medicine. Targeted research is needed to develop a new approach toward disease prevention and the reversing of early stage illnesses. To this end, we have teamed up with Swedish scientists and formed ProBion Innovation Sweden AB (PISA), a biotech research company, to study innovative use of probiotics. We believe microbiota affect expression of mediators in inflammatory pathways in intestinal cells, and in turn trigger diseases. When treated with probiotics, normal microbiota can be restored and aberrant mechanisms that lead to diseases can be reversed.

Meet The Board

ProBion innovation Sweden AB (PISA)

Katarina Ejeskär

Chief Research Officer

Victoria Rotter Sopasakis

Chief Executive Officere

Yvonne Wettergren

Chairman Of The Board

Charles Hanson

Board Member

Lennart Cedgård

Board Member

Partner with ProBion

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