Excessive stimulation due to bacterial dysbiosis and increased intestinal permeability may produce systemic inflammation due to dysfunctional responses of the adaptive immune system. The gut microbiota is involved in mucosal barrier integrity and immune function and can influence on mucosal immunity and systemic inflammation.


These microbes can produce hormones, neurotransmitters and neurotoxic metabolites that are linked to many different disorders such as rheumatic diseases, multiple sclerosis, celiac disease chronic fatigue syndrome, fibromyalgia and alcoholism.

In addition to the gut microbiota, bacterial communities of other sites such as the mouth, lung, and skin have been related to autoimmune diseases.


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