Probion Blog

  1. Technical Aspects of Probiotics - The Scientific Choice

    By Lennart Cedgård MD and CEO Wasa Medicals

    As being involved many years in the field of intestinal microecology, my interest in how to develop probiotics was initiated. There are some objectives that are to be looked upon if to create an "optimal performance" probiotic product.

    The choice of bacterial cultures

    Would it be best with just one single strain culture or a mixture of different cultures? Some advocate that a multi-strain product is positive, due to that there are different beneficial characteristics in the different cultures that will be added to each other. The performance of the different cultures could thus be synergistic, but this is not always the case as the more different strains introduced the more competition, which could inhibit the activities of the superior probiotic strains! It is also more difficult to achieve high standards of quality control in multi-strain products. Single strain probiotics may be so far a little easie

    Read more »
  2. Impact of Probiotics on the Immune and Nutritional System

    By Lennart Cedgård MD and CEO Wasa Medicals

    Probiotics has been defined as live microbial feed supplements that beneficially affect the host by improving the intestinal bacterial balance. Bacterial species commonly referred to as probiotic are lactic-acid producing bacteria such as Bifidobacterium spp., Lactobacillus spp. and Streptococcus spp., but also other microorganisms like the fungi S. boulardii have been used. There are many properties of probiotic bacteria that may help to improve the intestinal milieu like their metabolism, cell-wall structures and intracellular components.

    Suggested beneficial effect of probiotics:

    • Increased nutritional value (better digestibility, increased absorption of minerals and vitamins)
    • Promotion of intestinal lactose digestion
    • Positive influence on the intestinal microflora (antibiotics or radiation induced colitis)
    • Prevention of intestinal tract infections (bacteria or virus induc
    Read more »
  3. Small Intestine and Immune System

    By Lennart Cedgård MD and CEO Wasa Medicals

    The intestinal ecology is vital in both in the genesis, prevention and treatment of disease.

    The mucosal membrane of the intestine, which has an area of around 200m2, is under constant challenge by different kinds of antigens. Not only do we swallow food antigens (60-70 tons throughout a lifetime) and food-borne microbes, but also inhaled particles that become trapped in the respiratory tract and transported up to pharynx are finally swallowed and reach the intestine. Furthermore, the mucosal membrane of the intestine has intimate contact with the normal intestinal microflora. It is therefore not surprising that the intestine contains the largest accumulation of lymphoid tissues in the body. Eighty percent (!) of the lymphocytes in the body are situated in the intestinal wall, in the so-called gut-associated-lymphoid-tissue (GALT). They appear as aggregates in lymph nodul

    Read more »
  4. Intestinal Microflora - The Biggest Organ of Human Cells in Our Body

    By Lennart Cedgård MD and CEO Wasa Medicals

    There is a whole world of "microlife" in our intestines. The normal intestinal microflora build up a fantastic ecosystem, which is extremely complex and impossible to understand completely. What we know today is that our intestinal microflora consists of about E14 cells, which is ten times the number of human cells in our body. The normal microflora, sometimes called the biggest “organ” in the body has a weight of approximately 0,5-1,0 kg and at present it is estimated to consist of 1000 different species. However, recent genetic research shows that, when mapping the genome of the colonic bacteria only 35 per cent in previous times were to be identified and assigned to known bacteria. The remainder were unknown! We know today that the amount intestinal viruses are 10 times that of bacteria still to be defined.

    The stomach and the upper part of the small intestine contain low counts of bacteria (E3–5/ml gastric juice) due

    Read more »
  5. The Importance of Probiotics Consumption

    Probiotics: The Primary Food Supplement

    By Lennart Cedgård MD and CEO Wasa Medicals

    What are Probiotics?

    Probiotics have been defined as a live microbial feed supplement that beneficially influences the health of the host by improving the intestinal microflora. The use of probiotic bacteria in therapy is not a new invention. Yoghurt, containing probiotic bacteria have for hundreds of years been appreciated for its health bringing properties. Today, research is ongoing throughout the world to clarify the mechanism of probiotics. Intake of probiotic bacteria have many positive effects on health like:

    • Increasing the digestion and absorption of nutrients
    • Improvement of intestinal lactose digestion
    • Improving the intestinal milieu
    • Regulating the gut motility
    • Stimulating the immune system
    • Prevention of cancer
    • Reduction of catabolic products eliminated by kidney and liv
    Read more »
  6. Bloating and Probiotics

    Some of our clients ask about symptoms of bloating after initial probiotic use.

    In our experience bloating is a symptom of dysbiotic disorders in the gastrointestinal tract. When challenging this dysbiosis condition with viable and vigorous probiotics the normality is that these bad bacteria being guests in the guts for a long time start deteriorating. This means that their cell membranes are damaged and the bacteria go into lysis and endotoxins from their insides are getting exposed to the gut.tummy ache

    This will be experienced as the symptoms of getting worse. This is natural and those feeling like that often are the ones who will benefit the most from ProBion. This is just a sign of efficient load of therapeutic quality probiotics. 10-20% of Individuals may experience this and this is handled by starting with low dosage

    Read more »
  7. Intestinal microbiota in patients with colon cancer is altered by probiotic intervention

    Summary of the study and findings

    published in BMJ Open Gastroenterology in July 2017

    A clinical study was conducted by the Sahlgrenska Academy at University of Gothenburg, Sweden to find out whether the use of probiotics can alter the composition of intestinal bacteria in humans with colon cancer. Previous studies have demonstrated beneficial effects of probiotic bacteria in reducing mucosal inflammation and colon tumour development in animals, but supporting clinica data in humans were limited. The Swedish study involved 15 patients with colon cancer at Sahlgrenska University Hospital. Eight of them were given two tablets a day of ProBion Clinica, the brand chosen as the beneficial probiotics for the study. The other 7 colon cancer patients, together with another 21 non-cancer patients served as the control group and were given no probiotic intervention.

    Co

    Read more »
  8. Diarrhea and Probiotics

    The reasons for getting diarrhea can be many; from various infections, antibiotics use, Inflammatory Bowel Disease (IBD), Irritable Bowel Disease (IBS) or intense endurance exercise. In common for all these conditions they influence our gut microbiota, and all benefit from treatment with probiotics [1]. It is known that a changed microbiota can give bile salt deconjugation changes leading to changes in stool volume and consistency. Other important functions of the gut microbiota is metabolic (salvages calories, production of short-chain fatty acids, amino acids, vitamin K and folic acid); prevention of colonization by pathogens and immunologic functions [2].

    Antibiotics cause diarrhea by several mechanisms, one is that some antibiotics decrease the concentrations of anaerobes, leading to reduced metabolism of carbohydrates and a resultant osmotic diarrhea. Also, during, and in the re

    Read more »
  9. Autoimmune diseases and other health disorders.

    Excessive stimulation due to bacterial dysbiosis and increased intestinal permeability may produce systemic inflammation due to dysfunctional responses of the adaptive immune system. The gut microbiota is involved in mucosal barrier integrity and immune function and can influence on mucosal immunity and systemic inflammation.


    These microbes can produce hormones, neurotransmitters and neurotoxic metabolites that are linked to many different disorders such as rheumatic diseases, multiple sclerosis, celiac disease chronic fatigue syndrome, fibromyalgia and alcoholism.

    In addition to the gut microbiota, bacterial communities of other sites such as the mouth, lung, and skin have been related to autoimmune diseases.


    1. The role of the gut and microbes in the pathogenesis of spondyloarthritis. Asquith M, Elewaut D, Lin P, Rosenbaum JT
    Read more »
  10. Intestinal Microflora, Immune System and Probiotics

    The Intestinal Microflora, the Immune System and Probiotics.

    Lennart Cedgård, MD, GM Wasa Medicals, Gothenburg

    Anna Widell BSc in Bioscience, Wasa Medicals, Gothenburg.

    Today there is great scientific interest in the functions of the intestine and the action of intestinal microflora. Research on these issues is ongoing all over the world and one of the main issues is how the intestinal microflora influences the immune system and what effect supplementation of probiotics might have on the immune system.

    The intestinal microflora and the immune system

    There are an enormous number of bacteria colonising our intestines. These bacteria are referred to as " the normal intestinal microflora". The total amount of bacteria colonising our bodies and above all our intestines is ten times higher than the amount of the cells of the body. It follows that 90% of our body

    Read more »
Page